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Pavla Kopecková Selected Research

N-(2-hydroxypropyl)methacrylamide

11/2009Antitumor efficacy of colon-specific HPMA copolymer/9-aminocamptothecin conjugates in mice bearing human-colon carcinoma xenografts.
9/2008Combination chemotherapy and photodynamic therapy with fab' fragment targeted HPMA copolymer conjugates in human ovarian carcinoma cells.
5/2008Synthesis and biological evaluation of disulfide-linked HPMA copolymer-mesochlorin e6 conjugates.
2/2007Biodistribution and pharmacokinetics of colon-specific HPMA copolymer--9-aminocamptothecin conjugate in mice.
5/2006HPMA copolymer-bound doxorubicin induces apoptosis in ovarian carcinoma cells by the disruption of mitochondrial function.
5/2004HPMA copolymer-bound doxorubicin induces apoptosis in human ovarian carcinoma cells by a Fas-independent pathway.
11/2003Free and N-(2-hydroxypropyl)methacrylamide copolymer-bound geldanamycin derivative induce different stress responses in A2780 human ovarian carcinoma cells.
8/2003Subcellular trafficking of HPMA copolymer-Tat conjugates in human ovarian carcinoma cells.
6/2003Mechanisms of cytotoxicity in human ovarian carcinoma cells exposed to free Mce6 or HPMA copolymer-Mce6 conjugates.
1/2003Tat-conjugated synthetic macromolecules facilitate cytoplasmic drug delivery to human ovarian carcinoma cells.
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Pavla Kopecková Research Topics

Disease

12Carcinoma (Carcinomatosis)
11/2009 - 01/2002
7Neoplasms (Cancer)
02/2010 - 05/2004
3Osteoporosis
12/2007 - 07/2006
2Prostatic Neoplasms (Prostate Cancer)
04/2010 - 05/2009
2Colonic Neoplasms (Colon Cancer)
02/2007 - 08/2002
2Ovarian Neoplasms (Ovarian Cancer)
05/2006 - 01/2003
1Musculoskeletal Diseases (Musculoskeletal Disease)
02/2010
1Osteosarcoma (Osteogenic Sarcoma)
01/2009
1Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome)
01/2009
1Neoplasm Metastasis (Metastasis)
01/2009
1Bone Resorption
09/2007
1Bone Diseases (Bone Disease)
07/2006
1Arthritis (Polyarthritis)
10/2004
1Necrosis
06/2003
1Rheumatoid Arthritis
07/2002

Drug/Important Bio-Agent (IBA)

19hydroxypropyl methacrylateIBA
04/2010 - 01/2002
11N-(2-hydroxypropyl)methacrylamideIBA
11/2009 - 08/2002
3PolymersIBA
01/2009 - 02/2007
3Pharmaceutical PreparationsIBA
09/2008 - 01/2003
3Immunoglobulin Fab FragmentsIBA
09/2008 - 01/2002
3Doxorubicin (Adriamycin)FDA LinkGeneric
05/2006 - 01/2003
3CaspasesIBA
05/2006 - 06/2003
2AntibodiesIBA
05/2009 - 09/2008
2AntigensIBA
05/2009 - 09/2003
2meso-chlorin e(6) monoethylene diamineIBA
09/2008 - 06/2003
2Cell-Penetrating PeptidesIBA
08/2003 - 01/2003
19-aminocamptothecinIBA
11/2009
1Angiogenesis InhibitorsIBA
01/2009
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2009
1Biological ProductsIBA
09/2008
1ThiophenesIBA
09/2008
1DisulfidesIBA
05/2008
1Alendronate (Alendronate Sodium)FDA LinkGeneric
09/2007
1Diphosphonates (Bisphosphonates)IBA
09/2007
1ApatitesIBA
09/2007
1Serum AlbuminIBA
10/2004
1Evans Blue (Blue, Evans)FDA Link
10/2004
1Fluorescent Dyes (Fluorescent Probes)IBA
05/2004
1Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
05/2004
1FITC-annexin A5IBA
05/2004
1Caspase 3 (Caspase-3)IBA
05/2004
1Caspase 8 (Caspase-8)IBA
05/2004
1geldanamycinIBA
11/2003
117- (3- aminopropylamino)- 17- demethoxygeldanamycinIBA
11/2003
1Immunoglobulin FragmentsIBA
09/2003
1poly(ethylene glycol)-co-poly(ethyleneimine)IBA
09/2003
1PolyethyleneimineIBA
09/2003
1Surface Antigens (Surface Antigen)IBA
09/2003
1Sulfides (Thioethers)IBA
06/2003
1Fluorescein-5-isothiocyanate (FITC)IBA
06/2003
1Photosensitizing Agents (Photosensitizers)IBA
06/2003
1LactoseFDA LinkGeneric
08/2002
1GlycosidesIBA
08/2002
1GlycoconjugatesIBA
08/2002
1beta-galactosideIBA
08/2002
1SugarsIBA
08/2002
1Galactose (Galactopyranose)FDA LinkGeneric
08/2002
1GalactosamineIBA
08/2002
1LectinsIBA
08/2002
1Galectins (Galectin)IBA
08/2002
1Proteins (Proteins, Gene)FDA Link
07/2002
1Cathepsin KIBA
07/2002
1EnzymesIBA
07/2002

Therapy/Procedure

4Therapeutics
02/2010 - 12/2007
3Photochemotherapy (Photodynamic Therapy)
09/2008 - 01/2003
1Combination Drug Therapy (Combination Chemotherapy)
09/2008
1Drug Therapy (Chemotherapy)
01/2003